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alk5 target  (AstraZeneca ltd)

 
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    AstraZeneca ltd alk5 target
    Alk5 Target, supplied by AstraZeneca ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/alk5 target/product/AstraZeneca ltd
    Average 90 stars, based on 1 article reviews
    alk5 target - by Bioz Stars, 2026-03
    90/100 stars

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    BEAS-2Bcells transfected with TLR3 targeted siRNA were infected with RSV for 44 hours prior to the addition of dexamethasone (30nM, Dex) or vehicle for 4 hours. TLR3 siRNA reduced TLR3 mRNA expression (A) , prevented viral infection (RSV or RV)-induced TGF-β expression (B ), and attenuated RSV (C) or RV (D) -impaired Dex-induced gene expression. Data are presented as mean ± SEM for n = 4–5 independent experiments. *P<0.05, **P<0.01 ***P<0.001.

    Journal: PLoS Pathogens

    Article Title: Glucocorticoid Insensitivity in Virally Infected Airway Epithelial Cells Is Dependent on Transforming Growth Factor-β Activity

    doi: 10.1371/journal.ppat.1006138

    Figure Lengend Snippet: BEAS-2Bcells transfected with TLR3 targeted siRNA were infected with RSV for 44 hours prior to the addition of dexamethasone (30nM, Dex) or vehicle for 4 hours. TLR3 siRNA reduced TLR3 mRNA expression (A) , prevented viral infection (RSV or RV)-induced TGF-β expression (B ), and attenuated RSV (C) or RV (D) -impaired Dex-induced gene expression. Data are presented as mean ± SEM for n = 4–5 independent experiments. *P<0.05, **P<0.01 ***P<0.001.

    Article Snippet: Pre-validated siRNA targeting ALK5 and TLR3 (Invitrogen) was transfected using Lipofectamine RNAiMAX (Invitrogen) as described previously [ ].

    Techniques: Transfection, Infection, Expressing

    The respiratory viral infection or Poly(I:C) stimulation activates the TLR3-ERK1/2 pathway, to induce TGF-β activity, which is a key mediator of the GC impairment. Modulation of TGF-β expression or activity is a potential strategy for restoring GC sensitivity during the respiratory viral infection.

    Journal: PLoS Pathogens

    Article Title: Glucocorticoid Insensitivity in Virally Infected Airway Epithelial Cells Is Dependent on Transforming Growth Factor-β Activity

    doi: 10.1371/journal.ppat.1006138

    Figure Lengend Snippet: The respiratory viral infection or Poly(I:C) stimulation activates the TLR3-ERK1/2 pathway, to induce TGF-β activity, which is a key mediator of the GC impairment. Modulation of TGF-β expression or activity is a potential strategy for restoring GC sensitivity during the respiratory viral infection.

    Article Snippet: Pre-validated siRNA targeting ALK5 and TLR3 (Invitrogen) was transfected using Lipofectamine RNAiMAX (Invitrogen) as described previously [ ].

    Techniques: Infection, Activity Assay, Expressing